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Drug Interactions Fluvoxamine The effect of fluvoxamine on the pharmacokinetics of tizanidine was studied in 10 healthy subjects. In single-dose study where patients kupite poceni zanaflex s blizko were not titrated, two-thirds of patients given mg of Zanaflex experienced hypotension, which may be minimized by titration of dose. Your doctor should prescribe lower dose, and may have to monitor and adjust your dosage until safe and appropriate individual dose is determined. Concomitant use of tizanidine with CYP1A2 inhibitors should ordinarily be avoided.

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